Infection Guide — How to Cure Infected Wounds

How do you spot an infection before it becomes sepsis?

Check each injured limb in the health panel for infection progress, discoloration on the sprite, and escalating moodles. Community references checked on 2026-11-10 label stages from swollen wounds to dark pus, rapid spread, and necrosis (community-reported thresholds). The official store page does not spell out numbers—it only states you must fight infected wounds, so treat moodles and icons as your authority.

Purple-green limb tints can appear before some moodles in community notes—especially valuable if you play modes that hide early warnings.

What should you do first when a limb becomes infected?

Apply the medical guide sequence: stop bleeding, then disinfect, then long-term hygiene.

1. Close open bleeds on the same limb via the bleeding workflow. Community-reported formulas raise infection acquisition when bleeding and torn skin overlap.
2. Disinfect using antiseptic items named in community references (glowplant fruit, crafted antiseptics, life-pod showers—community-reported item list).
3. Craft or apply sterile dressings once ingredients are available. Official demo-era footage shows the Sterilized dressing recipe screen with ingredient rows; use crafting recipes to track what your run has unlocked.
4. Rest and feed — Community immunity notes tie infection speed to hunger, thirst, dirtiness, radiation, and antibiotics. The store page’s resilience and mood systems reinforce that neglected subjects fare worse.

Which treatments lower infection progress?

Injection minigames (syringe on limb) appear in official trailers for medical fluids. Reserve injectable cures for situations where topical disinfection cannot keep pace—after reading labels in your inventory, not from memory of wiki tables.

How does immunity interact with infection?

Community-reported immunity runs on a percentage-like scale:

• Low immunity moodles warn that infections become far more dangerous.
• High immunity—often from antibiotics and good maintenance—can slow or even reverse progress on disinfected limbs (community-reported math).

Official materials mention Resilience as a character trait; pairing trait choice with antibiotic stock is a legitimate long-run strategy even though exact trait modifiers are not confirmed in first-party text.

Poor mood from the store description’s “doom and gloom” line is not a direct infection stat, but it correlates with risky play (skipping rest stops), which indirectly feeds infection.

When should you amputate or abandon a deep run?

Community-reported life-threatening infection moodles mention spread to other limbs, necrosis, and sepsis as the stop-loss triggers. If total infection load across the body pushes sepsis counters, continuing down Deeper Gravel Lands or deeper layers without sterile stock is often worse than extracting.

Amputation requires cutting tools and a minigame in community references—only consider it when moodles explicitly demand it, not at the first purple tint.

Common mistakes that waste antibiotics

• Treating infection while a limb is still openly bleeding, doubling exposure rates (community-reported).
• Skipping disinfection because pain feels manageable—community base progress is +7.2 per minute before modifiers.
• Ignoring dirtiness and radiation, which community immunity tables punish even if HP looks fine.
• Confusing heart crises with infection — unstable ECG belongs in fibrillation, not this checklist.

For holistic run planning, cross-link beginner guide pacing and stash sterile kits before biomes with poison or spider enemies named in community bestiaries (enemy names community-reported).

Sources checked

• https://store.steampowered.com/app/4576490/Casualties_Unknown/ (“fight infected wounds” feature text)
• https://casualtiesunknown.miraheze.org/wiki/Infection (progress, immunity, treatments — community-reported)
• https://casualtiesunknown.miraheze.org/wiki/Blood_(mechanic) (bleeding × infection chance — community-reported)
• Official trailer frames showing the demo-era crafting menu (Sterilized dressing recipe), 2026-11-10

Last checked 2026-11-10 against the sources above, game version 1.0.

Screenshots and trailer frames: official Steam store page and trailers, © Orsoniks / Oro Interactive.